ACTA VETERINARIA ET ZOOTECHNICA SINICA ›› 2016, Vol. 47 ›› Issue (4): 637-644.doi: 10.11843/j.issn.0366-6964.2016.04.001

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Research Progress of Long Noncoding RNAs in the Regulation of Skeletal Muscle Development

ZHAN Si-yuan,LI Li,WANG Lin-jie,ZHONG Tao,ZHANG Hong-ping*   

  1. (Key Laboratory of Farm Animal Genetic Resources Exploration and Innovation of Sichuan Province,Sichuan Agricultural University,Chengdu 611130,China )
  • Received:2015-06-24 Online:2016-04-23 Published:2016-04-23

Abstract:

Long non-coding RNAs(lncRNAs)are a novel class of RNAs,which are longer than 200 nucleotides and have no protein-coding potential.In comparison with short noncoding RNAs which was studied extensively,a variety of long noncoding RNAs account for the majority of the transcripts in mammalian genome and the functions of lncRNAs are little understood.The recent studies have indicated that lncRNAs’ function involved in epigenetic modification,transcriptional regulation,cell differentiation,embryonic development and disease occurrence.In this review,we summarized the classification and molecular mechanisms of lncRNA,and research advances in the regulation of skeletal muscle development and domestic animal.

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